If the idea of a simple quilt seems incompatible with that of modern luxury, you’ve never been to the Charles Hotel. Combining the best of New England’s past with the vibrancy of its present, this hotel is where the rich and famous come to take in Boston’s scenery, including Ben Affleck and Bill Clinton. Guest rooms are simple yet refined; quilts top the beds, accompanied by pine entertainment centers, navy blue accent pillows, and soft lighting. Suites offer appealing plum and blue combinations, with built-in bookcases adding an at-home feel. A few minutes away from downtown, the Charles Hotel basks in the intellectual diversity of nearby Harvard. Stroll the campus, browse the many bookstores lining Harvard Square, or catch a performance at the American Repertory Theatre. Jump-start your evening with a little jazz at Regattabar, whose intimate stage and open, airy dining room set the mood for fun. Rialto and Noir offer two ways to close out the night, with savory Mediterranean dishes and after-dinner cocktails, respectively.